Smoking, dietary factors and major age-related eye disorders: an umbrella review of systematic reviews and meta-analyses

BackgroundThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucom...

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Published inBritish journal of ophthalmology Vol. 108; no. 1; pp. 51 - 57
Main Authors Kai, Jia-Yan, Zhou, Miao, Li, Dan-Lin, Zhu, Ke-Yao, Wu, Qian, Zhang, Xiao-Feng, Pan, Chen-Wei
Format Journal Article
LanguageEnglish
Published BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.01.2024
BMJ Publishing Group LTD
Subjects
Bias
Blindness
Cataract - epidemiology
Cataract - etiology
Cataracts
Credibility
Degeneration
Diabetic retinopathy
Diet
Disease prevention
Eye diseases
Glaucoma
Humans
Lens and cataract
Macula
Macular degeneration
Macular Degeneration - epidemiology
Macular Degeneration - etiology
Meta-analysis
Meta-Analysis as Topic
Polyunsaturated fatty acids
Public health
Retina
Sensitivity analysis
Smoking - adverse effects
Systematic review
Systematic Reviews as Topic
Visual impairment
China
Glaucoma
Macula
Retina
Degeneration
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Abstract BackgroundThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy.MethodsWe searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed.ResultsIn total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract.ConclusionsSmoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.PROSPERO registration numberCRD42022339082.
AbstractList BackgroundThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy.MethodsWe searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed.ResultsIn total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract.ConclusionsSmoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.PROSPERO registration numberCRD42022339082.
There is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy.BACKGROUNDThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy.We searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed.METHODSWe searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed.In total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract.RESULTSIn total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract.Smoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.CONCLUSIONSSmoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.CRD42022339082.PROSPERO REGISTRATION NUMBERCRD42022339082.
There is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy. We searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed. In total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract. Smoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review. CRD42022339082.
Author Zhu, Ke-Yao
Kai, Jia-Yan
Zhou, Miao
Li, Dan-Lin
Wu, Qian
Pan, Chen-Wei
Zhang, Xiao-Feng
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  fullname: Kai, Jia-Yan
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  surname: Zhou
  fullname: Zhou, Miao
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  surname: Zhu
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  surname: Wu
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  surname: Pan
  fullname: Pan, Chen-Wei
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36575624$$D View this record in MEDLINE/PubMed
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Keywords Glaucoma
Macula
Retina
Degeneration
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Snippet BackgroundThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an...
There is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella...
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StartPage 51
SubjectTerms Bias
Blindness
Cataract - epidemiology
Cataract - etiology
Cataracts
Credibility
Degeneration
Diabetic retinopathy
Diet
Disease prevention
Eye diseases
Glaucoma
Humans
Lens and cataract
Macula
Macular degeneration
Macular Degeneration - epidemiology
Macular Degeneration - etiology
Meta-analysis
Meta-Analysis as Topic
Polyunsaturated fatty acids
Public health
Retina
Sensitivity analysis
Smoking - adverse effects
Systematic review
Systematic Reviews as Topic
Visual impairment
Title Smoking, dietary factors and major age-related eye disorders: an umbrella review of systematic reviews and meta-analyses
URI https://bjo.bmj.com/content/108/1/51.full
https://www.ncbi.nlm.nih.gov/pubmed/36575624
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Volume 108
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