Smoking, dietary factors and major age-related eye disorders: an umbrella review of systematic reviews and meta-analyses

• Published in: British journal of ophthalmology Vol. 108; no. 1; pp. 51 - 57
• Main Authors: Kai, Jia-Yan, Zhou, Miao, Li, Dan-Lin, Zhu, Ke-Yao, Wu, Qian, Zhang, Xiao-Feng, Pan, Chen-Wei
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.01.2024; BMJ Publishing Group LTD
• Subjects: Bias; Blindness; Cataract - epidemiology; Cataract - etiology; Cataracts; Credibility; Degeneration; Diabetic retinopathy; Diet; Disease prevention; Eye diseases; Glaucoma; Humans; Lens and cataract; Macula; Macular degeneration; Macular Degeneration - epidemiology; Macular Degeneration - etiology; Meta-analysis; Meta-Analysis as Topic; Polyunsaturated fatty acids; Public health; Retina; Sensitivity analysis; Smoking - adverse effects; Systematic review; Systematic Reviews as Topic; Visual impairment; China; Glaucoma; Macula; Retina; Degeneration
• ISSN: 0007-1161; 1468-2079; 1468-2079
• DOI: 10.1136/bjo-2022-322325

BackgroundThere is accumulating evidence of the associations between age-related eye diseases (AREDs) and smoking or dietary factors. We aimed to provide an umbrella review of the published literature pertaining to smoking or dietary intake as risk factors for major AREDs including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy.MethodsWe searched for pertinent systematic reviews or meta-analyses in PubMed and Web of Science until 16 April 2022. We reperformed the meta-analysis of each association using random effects models. The heterogeneity and 95% prediction interval were calculated. The presence of small-study effect or excess significance bias was also assessed.ResultsIn total, 64 associations from 25 meta-analyses and 41 associations from 10 qualitative systematic reviews were evaluated. There was convincing (class I) evidence for only one association, namely current smoking and cataract. Two factors had highly suggestive (class II) evidence, namely ever smoking associated with cataract and fish consumption associated with AMD. We also found suggestive (class III) evidence for associations between the dietary intake of omega-3 polyunsaturated fatty acid, lutein, zeaxanthin, vitamin C and the risk of cataract.ConclusionsSmoking as a risk factor for cataract was the most robust association we identified. We also identified several dietary elements associated with AREDs. Large prospective studies are warranted to further examine the associations discussed in this review.PROSPERO registration numberCRD42022339082.