A ‘smart’ type of Cushing's syndrome

• Published in: European journal of endocrinology Vol. 157; no. 6; pp. 779 - 781
• Main Authors: Razenberg, A J, Elte, J W F, Rietveld, A P, van Zaanen, H C T, Cabezas, M Castro
• Format: Journal Article
• Language: English
• Published: Colchester BioScientifica 01.12.2007; Portland Press
• Subjects: Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Biological and medical sciences; Case Report; Cushing Syndrome - chemically induced; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Humans; Hydrocortisone - urine; Hypertension - chemically induced; Medical sciences; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Sodium Oxybate - adverse effects; Substance-Related Disorders - complications; Vertebrates: endocrinology; Endocrinopathy; Hyperadrenocorticism; Adrenal cortex diseases; Endocrinology; Adrenal gland diseases; Cushing syndrome
• ISSN: 0804-4643; 1479-683X
• DOI: 10.1530/EJE-07-0538

Cushing's syndrome results from lengthy and inappropriate exposure to excessive concentrations of either endogenous or exogenous glucocorticoids. This case report describes a patient with a novel type of Cushing's syndrome due to the use of party drugs. A 35-year-old woman had gained 8 kg body weight in 5 months and complained of anxiety. She showed a Cushing-like appearance and mild hypertension (blood pressure, BP 150/95 mmHg). She reported daily use of increasing doses of γ-hydroxybutyric acid (GHB), a popular party drug. ACTH plasma levels were in the upper normal range (41 ng/l), with normal plasma cortisol (0.36 μmol/l). She showed an abnormal overnight 1 mg dexamethasone suppression test (cortisol 0.38 μmol/l). The urinary excretion of free cortisol in 24 h was also increased (0.47 μmol/24 h). CT scanning of the abdomen showed normal adrenals. After stopping GHB intake she lost 7 kg body weight and her BP normalized (BP 135/80 mmHg). GHB is a popular party drug in the Netherlands, but it is also used as a narcotic and for the treatment of narcolepsy. We hypothesize that GHB may bind to the pituitary gland γ-aminobutyric acid-B receptors leading to ACTH overproduction.