SUSCEPTIBILITY OF INBRED MOUSE STRAINS TO INFECTION WITH THREE SPECIES OF METAGONIMUS PREVALENT IN THE REPUBLIC OF KOREA

• Published in: The Journal of parasitology Vol. 91; no. 1; pp. 12 - 16
• Main Authors: Guk, Sang-Mee, Park, Jin-Young, Seo, Min, Han, Eun-Taek, Kim, Jae-Lip, Chai, Jong-Yil
• Format: Journal Article
• Language: English
• Published: Lawrence, KS American Society of Parasitologists 01.02.2005; Allen Press Inc
• Subjects: Animals; Animals, Laboratory; Biological and medical sciences; DEVELOPMENT; Disease Models, Animal; Disease Susceptibility; Fecundity; Fertility; Fishes; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Haplotypes; Heterophyidae - growth & development; Heterophyidae - immunology; Heterophyidae - physiology; Host-Parasite Interactions; Inbred strains; Inbreeding; Infections; Invertebrates; Korea; Laboratory animals; Life tables; Male; Metagonimus; Metagonimus yokogawai; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains - parasitology; Parasite hosts; Parasites; Parasitology; Rodents; Sexual Maturation; Susceptibility; Trematode Infections - immunology; Trematode Infections - parasitology; Worms; Asia; Korea; South Korea; Infection; Vertebrata; Mammalia; Mouse; Rodentia; Helmintha; Plathelmintha; Parasite; Invertebrata; Trematoda
• ISSN: 0022-3395; 1937-2345
• DOI: 10.1645/GE-367R

Susceptibility of inbred mouse strains to Metagonimus yokogawai, Metagonimus miyatai, and Metagonimus takahashii infections was studied using BALB/c, ddY, C57BL/6J, C3H/HeN, and A/J mice, with H-2 haplotypes d, s, b, k, and a, respectively. Two hundred metacercariae were orally fed to each mouse, and the worm recovery rates (WRR), worm dimensions, and intrauterine egg numbers were measured at days 3, 7, 14, 21, and 28 postinfection (PI). On day 14 PI, the WRR of M. yokogawai was highest in ddY mice (average, 62.2%); those of M. miyatai and M. takahashii were highest in ddY (19.5%) and BALB/c mice (10.4%), respectively; worm maturation was best in C3H/HeN (M. yokogawai), C57BL/6J (M. miyatai), and ddY mice (M. takahashii). All mouse strains showed higher susceptibility to infection with M. yokogawai than with M. miyatai or M. takahashii. The results show that susceptibility of mice to Metagonimus infection varies according to mouse strain and parasite species but is suggested to be independent of the mouse H-2 haplotype.