Macular structure–function relationship at various spatial locations in glaucoma

• Published in: British journal of ophthalmology Vol. 99; no. 10; pp. 1412 - 1418
• Main Authors: Kim, Soa, Lee, Jin Young, Kim, Seon-Ok, Kook, Michael S
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.10.2015
• Subjects: Algorithms; Cross-Sectional Studies; Defects; Female; Follow-Up Studies; Glaucoma; Glaucoma - diagnosis; Glaucoma - physiopathology; Humans; Intraocular Pressure; Macula Lutea - pathology; Macula Lutea - physiopathology; Macular degeneration; Male; Middle Aged; Nerve Fibers - pathology; Optic nerve; Optics; Prospective Studies; Retinal Ganglion Cells - pathology; Tomography; Tomography, Optical Coherence; Visual Acuity; Visual Field Tests; Visual Fields; California; Glaucoma; Macula; Field of vision
• ISSN: 0007-1161; 1468-2079; 1468-2079
• DOI: 10.1136/bjophthalmol-2014-306538

Background/aimsTo study whether the structure–function (S-F) relationship in glaucoma differs according to macular location using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry 10-2 and 24-2 visual fields (VFs).MethodsWe enrolled 151 eyes of 151 healthy, preperimetric and perimetric glaucomatous subjects. Macular ganglion cell-inner plexiform layer thicknesses at different parafoveal locations were measured using Cirrus SD-OCT. The mean sensitivity of 10–2 and 24–2 VFs was recorded in the decibel and 1/L scales. The topographic relationships between structure and function were assessed at different parafoveal and hemimacular locations using ‘weighted’ correlation coefficients. The strength of S-F relationships between macular ganglion cell-inner plexiform layer thickness measurements and VF mean sensitivity in various parafoveal locations and in superior and inferior hemimacula was compared using Steiger's test.ResultsThe temporal parafoveal sector showed a significantly greater S-F relationship in each hemimacula compared with other parafoveal sectors (p<0.05). The inferior hemimacula showed a significantly greater S-F relationship than superior hemimacula (p<0.001).ConclusionsThe strength of the S-F associations at the temporal parafoveal location is significantly greater than that of the central or nasal parafoveal location in each hemimacula. The strength of the S-F association is significantly greater in the inferior hemimacula than in the superior hemimacula.