Use of Rhodamine B as a Biomarker for Oral Plague Vaccination of Prairie Dogs

Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested a...

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Bibliographic Details
Published inJournal of wildlife diseases Vol. 47; no. 3; pp. 765 - 768
Main Authors Fernandez, Julia Rodriguez-Ramos, Rocke, Tonie E.
Format Journal Article
LanguageEnglish
Published United States Wildlife Disease Association 01.07.2011
Subjects
Administration, Oral
Animals
Animals, Wild
Biomarkers
Female
Fluorescent Dyes - analysis
Male
Plague
Plague - prevention & control
Plague - veterinary
Plague Vaccine - administration & dosage
prairie dog
rhodamine B
Rhodamines - analysis
Rodent Diseases - prevention & control
Sciuridae
SHORT COMMUNICATIONS
vaccination
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Summary:Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested as a potential biomarker for oral plague vaccination because it allows nonlethal sampling of animals through hair, blood, and feces. We found that RB is an appropriate marker for bait uptake studies of <60 days in black-tailed prairie dogs (C. ludovicianus) when used at concentrations <0.5% f bait mass dosed to deliver >10 mg RB per kg target animal mass. Whiskers with follicles provided the best sample for RB detection.
Bibliography:ObjectType-Article-1
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ISSN:0090-3558
1943-3700
DOI:10.7589/0090-3558-47.3.765