How to interpret a single cortisol measurement

Adrenal insufficiency can present with non-specific clinical features. Therefore, a single cortisol measurement is often included in the biochemical work-up of an unwell child. This article aims to review the diagnostic utility of a single cortisol measurement by outlining the physiological, clinica...

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Bibliographic Details
Published inArchives of disease in childhood. Education and practice edition Vol. 105; no. 6; pp. 347 - 351
Main Authors Shaunak, Meera, Blair, Joanne C, Davies, Justin Huw
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.12.2020
Subjects
Blood pressure
Brain cancer
Children & youth
Circadian rhythm
Glucose
Hormones
Hypoglycemia
Hyponatremia
Hypothalamus
Immunoassay
Laboratories
Neurosurgery
Pediatrics
Physiology
Pituitary gland
Steroids
general paediatrics
endocrinology
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Summary:Adrenal insufficiency can present with non-specific clinical features. Therefore, a single cortisol measurement is often included in the biochemical work-up of an unwell child. This article aims to review the diagnostic utility of a single cortisol measurement by outlining the physiological, clinical and technical factors affecting result interpretation. Clinical scenarios are used to illustrate how this test may be used in different commonly encountered situations in general paediatrics, with the aim of minimising the frequency of inconclusive results.
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SourceType-Scholarly Journals-1
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ISSN:1743-0585
1743-0593
DOI:10.1136/archdischild-2019-318431