Population-based assessment of vision-related quality of life in corneal disease: results from the CORE study

• Published in: British journal of ophthalmology Vol. 100; no. 5; pp. 588 - 593
• Main Authors: Vashist, Praveen, Gupta, Noopur, Tandon, Radhika, Gupta, Sanjeev K, Dwivedi, Sadanand, Mani, Kalaivani
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2016
• Subjects: Adolescent; Adult; Age; Blindness; Blindness - epidemiology; Blindness - psychology; Corneal Diseases - epidemiology; Corneal Diseases - psychology; Cross-Sectional Studies; Disease; Epidemiologic Studies; Female; Health care; Humans; India - epidemiology; Male; Middle Aged; Normal distribution; Occupations; Population; Prevalence; Quality of life; Quality of Life - psychology; Rural Population - statistics & numerical data; Sickness Impact Profile; Social impact; Sociodemographics; Statistical analysis; Surveys and Questionnaires; Vision, Low - epidemiology; Vision, Low - psychology; Vision, Ocular; Visual impairment; Visually Impaired Persons - psychology; Young Adult; India; Epidemiology; Cornea; Public health
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjophthalmol-2015-307619

ObjectiveTo assess the impact of corneal disease on vision-related quality of life (VR-QoL) in a rural North Indian population.DesignCross-sectional, population-based study.MethodsThe Corneal Opacity Rural Epidemiological (CORE) study included 12 899 participants from 25 randomly selected clusters of rural Gurgaon, Haryana, India, with the primary objective of determining the prevalence of corneal disease in the general population during July 2011 to January 2013. VR-QoL was assessed through Indian Vision Function questionnaire (IND-VFQ-33) in adult participants (aged ≥18 years) detected with corneal opacity and equal number of healthy controls (no ocular pathology with visual acuity of 6/6 binocularly) selected from the same clusters. Scores of the three subscales of IND-VFQ-33 (vision-specific mobility, psychosocial impact and visual symptoms) were computed, analysed and compared separately across various groups.ResultsOverall, 12 113 participants of all ages underwent detailed ophthalmic examination and VR-QoL was assessed in 435 cases with corneal disease and 435 controls without any ophthalmic disease. The diseased population had significantly higher scores and hence poorer VR-QoL across all three domains of vision function (scores of 28 vs 22; 6 vs 5 and 14 vs 9, respectively; p<0.0001) and the scores were inversely related with the level of visual impairment in patients with corneal disease. Patients with unilateral corneal disease also had poorer VR-QoL scores as compared with healthy controls (p<0.0001).ConclusionsVR-QoL is impaired in patients with corneal disease, more so in patients with corneal blindness. This is the first population-based study to document VR-QoL through IND-VFQ-33 in the Indian population with corneal disease.