New Hydrazide-hydrazone Derivatives of Quinoline 3-Carboxylic Acid Hydrazide: Synthesis, Theoretical Modeling and Antibacterial Evaluation
A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and H-1 NMR...
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Published in | Letters in organic chemistry Vol. 16; no. 5; pp. 430 - 436 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
SHARJAH
Bentham Science Publ Ltd
01.01.2019
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Subjects | |
Online Access | Get more information |
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Summary: | A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and H-1 NMR, C-13 NMR spectral data. The structural and Frontier Molecular Orbital (FMO) properties and the Density Functional Theory (DFT) calculations were conducted for the new compounds. The new hydrazide-hydrazones exhibited low to moderate antibacterial activity against Staphylococcus aureus and Esherichia coli in comparison with gentamycin. Among the tested compounds, compounds 9 and 13 were found to be the most active. Phthalimide derivative 2 of 3-quioline carboxylic acid hydrazide showed remarkable antibacterial activity. |
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ISSN: | 1570-1786 1875-6255 |
DOI: | 10.2174/1570178616666181227122326 |