Pregnancy and fertility-related adverse outcomes associated with Chlamydia trachomatis infection: a global systematic review and meta-analysis

• Published in: Sexually transmitted infections Vol. 96; no. 5; pp. 322 - 329
• Main Authors: Tang, Weiming, Mao, Jessica, Li, Katherine T, Walker, Jennifer S, Chou, Roger, Fu, Rong, Chen, Weiying, Darville, Toni, Klausner, Jeffrey, Tucker, Joseph D
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.08.2020; BMJ Publishing Group LTD
• Subjects: Abortion, Spontaneous - epidemiology; Bias; Birth weight; Chlamydia; Chlamydia Infections - epidemiology; Chlamydia trachomatis; Cost analysis; Endometritis - epidemiology; Female; Fertility; Fetal Membranes, Premature Rupture - epidemiology; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Small for Gestational Age; Infections; Infertility; Infertility, Female - epidemiology; Inflammatory diseases; Maternal & child health; Meta-analysis; Miscarriage; Obstetric Labor, Premature - epidemiology; Pelvic inflammatory disease; Pre-Eclampsia - epidemiology; Pregnancy; Pregnancy complications; Pregnancy Complications, Infectious - epidemiology; Pregnancy Outcome - epidemiology; Pregnancy, Ectopic - epidemiology; Premature Birth - epidemiology; Puerperal Infection - epidemiology; Quality; Reproductive Tract Infections - epidemiology; Review; Stillbirth; Stillbirth - epidemiology; Studies; Systematic review; women; Womens health; China; meta-analysis; chlamydia trachomatis; infertility; pregnancy; women
• ISSN: 1368-4973; 1472-3263; 1472-3263
• DOI: 10.1136/sextrans-2019-053999

BackgroundGenital chlamydia infection in women is often asymptomatic, but may result in adverse outcomes before and during pregnancy. The purpose of this study was to examine the strength of the relationships between chlamydia infection and different reproductive health outcomes and to assess the certainty of the evidence.MethodsThis review was registered and followed the Cochrane guidelines. We searched three databases to quantitatively examine adverse outcomes associated with chlamydia infection. We included pregnancy and fertility-related outcomes. We performed meta-analyses on different study designs for various adverse outcomes using unadjusted and adjusted analyses.ResultsWe identified 4730 unique citations and included 107 studies reporting 12 pregnancy and fertility-related outcomes. Sixty-eight studies were conducted in high-income countries, 37 studies were conducted in low-income or middle-income countries, and 2 studies were conducted in both high-income and low-income countries. Chlamydia infection was positively associated with almost all of the 12 included pregnancy and fertility-related adverse outcomes in unadjusted analyses, including stillbirth (OR=5.05, 95% CI 2.95 to 8.65 for case–control studies and risk ratio=1.28, 95% CI 1.09 to 1.51 for cohort studies) and spontaneous abortion (OR=1.30, 95% CI 1.14 to 1.49 for case–control studies and risk ratio=1.47, 95% CI 1.16 to 1.85 for cohort studies). However, there were biases in the design and conduct of individual studies, affecting the certainty of the overall body of evidence. The risk of adverse outcomes associated with chlamydia is higher in low-income and middle-income countries compared with high-income countries.ConclusionChlamydia is associated with an increased risk of several pregnancy and fertility-related adverse outcomes in unadjusted analyses, especially in low-income and middle-income countries. Further research on how to prevent the sequelae of chlamydia in pregnant women is needed.Trial registration numberCRD42017056818.