An Efficient One-Pot, Multicomponent Synthesis of 1, 3-Thiazolidin-4-Ones Using L-Proline as Catalyst in Water

An efficient methodology for the synthesis of 1,3-thiazolidin-4-ones using L-Proline as catalyst under aqueous conditions has been developed. The one-pot, multicomponent reaction of aromatic/heterocyclic aldehyde, aromatic amine and thioglycolic acid at room temperature give 1,3thiazolidin-4-ones in...

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Bibliographic Details
Published inLetters in organic chemistry Vol. 19; no. 1; pp. 9 - 13
Main Authors Gadkari, Yatin U., Shanbhag, Rajesh D., Telvekar, Vikas N.
Format Journal Article
LanguageEnglish
Published SHARJAH Bentham Science Publ Ltd 01.01.2022
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DESIGN
Multicomponent reaction
L-proline
E-factor
economical
thiazolidinone
water
GREEN
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Summary:An efficient methodology for the synthesis of 1,3-thiazolidin-4-ones using L-Proline as catalyst under aqueous conditions has been developed. The one-pot, multicomponent reaction of aromatic/heterocyclic aldehyde, aromatic amine and thioglycolic acid at room temperature give 1,3thiazolidin-4-ones in moderate to good yields. Further, the current approach is notably greener than traditional methods, with an E-factor of 3.1 and an eco scale score of 96. The developed protocol offers several features, such as being simple, environmentally benign, energy-efficient, economic, mild conditions, shorter reaction time.
ISSN:1570-1786
1875-6255
DOI:10.2174/1570178618666210119121734