Dengue Virus-1 Infection Did Not Alter the Behavioral Response of Aedes aegypti (Diptera: Culicidae) to DEET

No licensed vaccine or antiviral drug against dengue virus (DENV) is available; therefore, most of the effort to prevent this disease is focused on reducing vector–host interactions. One of the most widely accepted methods of blocking vector–human contact is to use insect repellents to interfere wit...

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Published inJournal of medical entomology Vol. 53; no. 3; pp. 687 - 691
Main Authors Sugiharto, Victor A., Murphy, Jittawadee R., Turell, Michael J., Olsen, Cara H., Stewart, V. Ann, Colacicco-Mayhugh, Michelle G., Grieco, John P., Achee, Nicole L.
Format Journal Article
LanguageEnglish
Published England Entomological Society of America 01.05.2016
Oxford University Press
Subjects
Aedes - physiology
Aedes - virology
Aedes aegypti
Animals
Aquatic insects
behavior
Behavior, Animal
DEET
dengue
Dengue - transmission
Dengue - virology
Dengue fever
Dengue Virus - physiology
Disease transmission
Humans
Insect Vectors - physiology
Insect Vectors - virology
Mosquitoes
Repellents
Vaccines
Vector-borne diseases
VECTOR/PATHOGEN/HOST INTERACTION, TRANSMISSION
Viruses
behavior
dengue
DEET
Aedes aegypti
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Summary:No licensed vaccine or antiviral drug against dengue virus (DENV) is available; therefore, most of the effort to prevent this disease is focused on reducing vector–host interactions. One of the most widely accepted methods of blocking vector–human contact is to use insect repellents to interfere with mosquito host-seeking behavior. Some arboviruses can replicate in the nervous system of the vector, raising the concern that arboviral infection may alter the insect behavioral response toward chemical stimuli. Three different Aedes aegypti (L.) mosquito cohorts: DENV-1-injected, diluent-injected, and uninjected were subjected to behavioral tests using a high-throughput screening system with 2.5% DEET and 0.14% DEET on 1, 4, 7, 10, 14, and 17 d postinjection. All test cohorts exhibited significant contact irritant or escape responses when they were exposed to 2.5% or 0.14% DEET. However, we found no biologically relevant irritancy response change in DENV-1-infected Ae. aegypti mosquitoes when they were exposed to DEET. Further studies evaluating the effects of other arboviral infections on insect repellents activity are necessary in order to provide better recommendation on the prevention of vector-borne disease transmission.
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ISSN:0022-2585
1938-2928
DOI:10.1093/jme/tjw030