THE EFFECTS OF SOME ANTI-INFLAMMATORY SUBSTANCES ON CARRAGEENIN-INDUCED GRANULOMATA

Carrageenin pellets, implanted subcutaneously in adrenalectomized rats, produced in 5 days compact, easily dissected granulomata. Accepted anti-inflammatory steroids administered as single daily subcutaneous injections or in the diet, but not as single daily oral doses, reduced the granuloma wet wei...

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Bibliographic Details
Published inJournal of endocrinology Vol. 25; no. 1; pp. 87 - 93
Main Authors ATKINSON, R M, JENKINS, L, TOMICH, E G, WOOLLETT, E A
Format Journal Article
LanguageEnglish
Published England BioScientifica 01.09.1962
Subjects
Anti-Inflammatory Agents
Carrageenan
Cortisone - pharmacology
Dexamethasone - pharmacology
Granuloma
Hydrocortisone - pharmacology
Methylphenidate - analogs & derivatives
Polysaccharides - toxicity
GRANULOMA/experimental
CORTISONE/pharmacology
DEXAMETHASONE/pharmacology
METHYLPHENIDATE/related compounds
HYDROCORTISONE/pharmacology
POLYSACCHARIDES/toxicology
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Summary:Carrageenin pellets, implanted subcutaneously in adrenalectomized rats, produced in 5 days compact, easily dissected granulomata. Accepted anti-inflammatory steroids administered as single daily subcutaneous injections or in the diet, but not as single daily oral doses, reduced the granuloma wet weight. The relative anti-inflammatory activities of cortisol, prednisolone and betamethasone, administered subcutaneously or in the diet, duplicated their relative clinical values. The relative activity of dexamethasone to cortisol was three times that reported on patients. Corticosterone acetate was weakly active in this test, desoxycorticosterone acetate increased granuloma weight, and oestrone, mepyramine maleate, mersalyl, progesterone, norethandrolone, testosterone propionate and Pitressin were inactive.
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0250087