INFLUENCE OF METHYLTESTOSTERONE AND CYPROTERONE ACETATE ON WOLFFIAN DUCT DIFFERENTIATION IN FEMALE RAT FOETUSES

In contrast to results in rabbit and dog foetuses, Wolffian duct stabilization in male rat foetuses was inhibited by cyproterone acetate. On the other hand, the stabilizing effect of methyltestosterone in female rat foetuses could be abolished even when excessive androgen doses were given. The hormo...

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Bibliographic Details
Published inJournal of endocrinology Vol. 47; no. 4; pp. 417 - NP
Main Authors Elger, W, Steinbeck, H, Cupceancu, B, Neumann, F
Format Journal Article
LanguageEnglish
Published England BioScientifica 01.08.1970
Subjects
Androgen Antagonists
Animals
Female
Fetus
Male
Methyltestosterone - antagonists & inhibitors
Methyltestosterone - pharmacology
Pregnancy
Pregnanes - pharmacology
Rats
Wolffian Ducts - drug effects
Wolffian Ducts - embryology
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Summary:In contrast to results in rabbit and dog foetuses, Wolffian duct stabilization in male rat foetuses was inhibited by cyproterone acetate. On the other hand, the stabilizing effect of methyltestosterone in female rat foetuses could be abolished even when excessive androgen doses were given. The hormonal factor(s) involved in normal Wolffian duct stabilization in male rat foetuses remains to be clarified.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0470417