The Chemoprotective Potentials of Alpha-lipoic Acid against Cisplatin-induced Ototoxicity: A Systematic Review

• Published in: Current medicinal chemistry Vol. 31; no. 23; p. 3588
• Main Authors: Lateef Al-Awsi, Ghaidaa Raheem, Arshed, Uzma, Arif, Anam, Ramírez-Coronel, Andrés Alexis, Alhassan, Muataz S, Mustafa, Yasser Fakri, Rahman, Ferry Fadzlul, Zabibah, Rahman S, Gupta, Jitendra, Iqbal, Muhammad Shahid, Iswanto, Acim Heri, Farhood, Bagher
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Animals; Antineoplastic Agents - adverse effects; Antioxidants - pharmacology; Cell Survival - drug effects; Cisplatin - adverse effects; Humans; Ototoxicity - prevention & control; Protective Agents - pharmacology; Thioctic Acid - pharmacology; biochemical parameters; alpha-lipoic acid; cisplatin; ototoxicity; chemotherapy; Cancer
• ISSN: 1875-533X
• DOI: 10.2174/0929867330666230509162513

Ototoxicity is one of the major adverse effects of cisplatin therapy which restrict its clinical application. Alpha-lipoic acid administration may mitigate cisplatin-induced ototoxicity. In the present study, we reviewed the protective potentials of alpha-lipoic acid against the cisplatin-mediated ototoxic adverse effects. Based on the PRISMA guideline, we performed a systematic search for the identification of all relevant studies in various electronic databases up to June 2022. According to the inclusion and exclusion criteria, the obtained articles (n=59) were screened and 13 eligible articles were finally included in the present study. The findings of experiments showed that cisplatin treatment significantly reduced the auditory cell viability in comparison with the control group; nevertheless, the alpha-lipoic acid co-administration protected the cells against the reduction of cell viability induced by cisplatin treatment. Moreover, the results of the auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests revealed a decrease in DPOAE and an increase in ABR threshold of cisplatin-injected animals; however, it was shown that alpha-lipoic acid co-treatment had an opposite pattern on the evaluated parameters. Other findings demonstrated that cisplatin treatment could significantly induce the biochemical and histopathological alterations in inner ear cells/tissue; in contrast, alpha-lipoic acid co-treatment ameliorated the cisplatin-mediated biochemical and histological changes. The findings of audiometry, biochemical parameters, and histological evaluation showed that alpha-lipoic acid co-administration alleviates the cisplatin-induced ototoxicity. The protective role of alpha-lipoic acid against the cisplatin-induced ototoxicity can be due to different mechanisms of anti-oxidant, anti-apoptotic, anti-inflammatory activities, and regulation of cell cycle progression.