Tiny Regulators in Viral Infection: Carving SARS-CoV-2 by miRNAs

Viruses are microscopic biological entities that can cause diseases. Viruses require a host cell to replicate and generate progeny. Once inside, viruses hijack the main cellular machinery for their benefit, disrupting cell functions and causing detrimental effects on cell physiology. MicroRNAs are s...

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Published inMicroRNA (Shariqah, United Arab Emirates) Vol. 11; no. 3; p. 185
Main Authors Martínez-Acuña, Natalia, Lozano-Sepúlveda, Sonia Amelia, Del Carmen Martínez-Guzmán, María, Rivas-Estilla, Ana María
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2022
Subjects
COVID-19 - genetics
Humans
MicroRNAs - genetics
RNA, Viral - genetics
SARS-CoV-2 - genetics
Virus Diseases - genetics
cytokine
RNA viruses
SARS-CoV-2
MicroRNA
storm
viral-microRNA
v-miRNAs features
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Summary:Viruses are microscopic biological entities that can cause diseases. Viruses require a host cell to replicate and generate progeny. Once inside, viruses hijack the main cellular machinery for their benefit, disrupting cell functions and causing detrimental effects on cell physiology. MicroRNAs are short, non-coding RNAs that regulate gene expression. Recent works have shown that cell-miRNAs can modulate antiviral defense during viral infection, and viruses can disrupt these existing miRNA networks. Furthermore, multiple RNA viruses encode their own miRNAs to evade the host immune response. In this review, we analyze the activities of both, miRNAs as pro-viral modulators and miRNAs as anti-viral agents and their relationship with the development of the disease.
ISSN:2211-5374
DOI:10.2174/2211536611666220816124650