Perineurioma of the sigmoid colon

• Published in: BMJ case reports Vol. 2018; p. bcr-2018-227170
• Main Authors: Jama, Guled M, Evans, Matthew, Fazal, Muhammad W, Singh-Ranger, Deepak
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 27.09.2018; BMJ Publishing Group
• Subjects: Antigens; Case reports; Colon; Colon, Sigmoid - diagnostic imaging; Colon, Sigmoid - innervation; Colon, Sigmoid - pathology; Colon, Sigmoid - surgery; Colonic Neoplasms - diagnostic imaging; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Colonoscopy; Diagnosis, Differential; Health surveillance; Hemoglobin; Humans; Images In; Male; Metastasis; Narrow Band Imaging - methods; Nerve Sheath Neoplasms - metabolism; Nerve Sheath Neoplasms - pathology; Nerve Sheath Neoplasms - surgery; Sigmoidoscopy - methods; Stains & staining; Treatment Outcome; Young Adult; endoscopy; pathology; gastroenterology
• ISSN: 1757-790X; 1757-790X
• DOI: 10.1136/bcr-2018-227170

Colonic perineuriomas, or fibroblastic polyps, are rare benign mucosal lesions comprising a proliferation of bland spindle cells expressing markers of perineurial differentiation.1 They are usually found in the rectum and sigmoid colon, although they have been reported proximal to the splenic flexure.2 With an estimated incidence of 0.1%–1.46% of all colonic polyps, they tend to be discovered incidentally in patients undergoing routine screening colonoscopy. Characteristic histological features include spindle cell proliferation within the lamina propria which often separates and distorts the colonic crypt architecture. [...]the neoplastic nature of the serrated variant means that they should be classified based on the criteria used for serrated colorectal polyps in general, making postpolypectomy surveillance in some cases appropriate.3 Learning points Colonic perineuromas are rare benign mucosal lesions; however, their characterisation is important in determining colonoscopic surveillance.