A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota

• Published in: Gut Vol. 67; no. 11; pp. 1974 - 1983
• Main Authors: Watson, Henry, Mitra, Suparna, Croden, Fiona C, Taylor, Morag, Wood, Henry M, Perry, Sarah L, Spencer, Jade A, Quirke, Phil, Toogood, Giles J, Lawton, Clare L, Dye, Louise, Loadman, Paul M, Hull, Mark A
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.11.2018
• Subjects: Aged; Arachidonic acid; Beverages; Cancer; Carcinogenesis; Chromatography, Liquid; Colorectal cancer; Cross-Over Studies; Diarrhea; Diet; Dietary Supplements; Docosahexaenoic acid; Eicosapentaenoic acid; Erythrocytes; Fatty acids; Fatty Acids - blood; Fatty Acids, Omega-3 - therapeutic use; Feces - microbiology; Female; Fish oils; Functional foods & nutraceuticals; Gastrointestinal Microbiome - drug effects; Healthy Volunteers; Humans; Hypotheses; Intervention; Intestinal microflora; Intestine; Liquid chromatography; Male; Mass Spectrometry; Mass spectroscopy; Metabolism; Metabolites; Microbiomes; Microbiota; Middle Aged; Nutrition research; Ostomy; Polymerase Chain Reaction; Polyunsaturated fatty acids; rRNA 16S; fatty acid; colorectal cancer; bacteria; nutritional supplement; omega-3

ObjectiveOmega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with antineoplastic activity. Therefore, we investigated...