Chiral NADH Model: Design, Synthesis, Asymmetric Reduction Reaction, and Fluorescence Characteristics

A new type of NADH model compound, which has six asymmetric carbon centers, has been synthesized by an efficient and convenient method. We used NADH models combined with enzymes in the asymmetric reduction. It was the first time that dehydrogenase combined with NADH models instead of inorganic catal...

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Bibliographic Details
Published inLetters in organic chemistry Vol. 19; no. 10; pp. 827 - 831
Main Authors Bai, Cui-Bing, Zhang, Lei-Yang, Wang, Nai-Xing, Yan, Zhan, Wu, Yue-Hua, Xu, Bao-Cai, Liu, Ning, Wang, Bo-Zhou, Tomasic, Vesna
Format Journal Article
LanguageEnglish
Published SHARJAH Bentham Science Publ Ltd 01.10.2022
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
NADH model
synthesis
NAD(P)H MODEL
NADH
fluorescence
PROGRESS
GUEST
HOST
ION
asymmetric reduction
dehydrogenase
HYDRIDE TRANSFER
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Summary:A new type of NADH model compound, which has six asymmetric carbon centers, has been synthesized by an efficient and convenient method. We used NADH models combined with enzymes in the asymmetric reduction. It was the first time that dehydrogenase combined with NADH models instead of inorganic catalysts, such as MgCl2, was used in the asymmetric reduction. Furthermore, the experimental results showed that the new NADH model has the strongest fluorescence emission properties compared to previously reported models.
ISSN:1570-1786
1875-6255
DOI:10.2174/1570178619666220127122333