GOITROGENIC ACTION OF COBALTOUS CHLORIDE IN THE GUINEA-PIG

Recently, Kriss, Carnes & Gross (1955) reported that prolonged treatment with cobaltous chloride caused hypothyroidism and thyroid hyperplasia in five patients suffering from anemia. Histological examination of biopsy specimens taken from the thyroid glands showed hypertrophy of the epithelium a...

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Published inActa endocrinologica (Copenhagen) Vol. 20; no. 4; pp. 351 - 354
Main Authors ANTILA, V, TELKKA, A, KUUSISTO, A N
Format Journal Article
LanguageEnglish
Published Denmark 01.12.1955
Subjects
Cobalt - pharmacology
Goiter
Guinea Pigs
COBALT/effects
GOITER/experimental
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Summary:Recently, Kriss, Carnes & Gross (1955) reported that prolonged treatment with cobaltous chloride caused hypothyroidism and thyroid hyperplasia in five patients suffering from anemia. Histological examination of biopsy specimens taken from the thyroid glands showed hypertrophy of the epithelium and paucity of the colloid. There was laboratory evidence of depressed thyroid function, which disappeared within several weeks after withdrawal of the cobalt therapy. In the work reported in the present paper, attempts were made to confirm the antithyroid effect of cobalt in animal experiments. MATERIAL AND METHODS Thirty male guinea-pigs, weighing about 450 gm., were used. Ten of them received daily intraperitoneal injections of cobaltous chloride as a saline solution in a dose of 2 mg./kg. of body weight (Group A) and ten animals in a dose of 8 mg./kg. of body weight (Group B), over a period of 30 days. Ten animals served as untreated controls. The animals were
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0200351