Ineffectiveness and Comparative Pathogenicity of Attenuated Rabies Virus Vaccines for the Striped Skunk (Mephitis mephitis)

• Published in: Journal of wildlife diseases Vol. 26; no. 1; pp. 99 - 102
• Main Authors: Rupprecht, C. E., Charlton, K. M., Artois, M., Casey, G. A., Webster, W. A., Campbell, J. B., Lawson, K. F., Schneider, L. G.
• Format: Journal Article
• Language: English
• Published: United States Wildlife Disease Association 01.01.1990; Wildlife Dis Assoc
• Subjects: Administration, Intranasal; Administration, Oral; Animals; Antibodies, Viral - biosynthesis; Carnivora; experimental study; Female; Male; Mephitidae; Mephitis mephitis; oral vaccination; pathogenesis; Rabies; Rabies - prevention & control; Rabies - veterinary; Rabies Vaccines - administration & dosage; Rabies Vaccines - adverse effects; Rabies Vaccines - immunology; Rabies virus - immunology; SHORT COMMUNICATIONS; skunk; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology
• DOI: 10.7589/0090-3558-26.1.99
• ISSN: 0090-3558

Three attenuated rabies virus vaccines (SAD-B19, ERA/BHK-21, AZA 2) were compared for efficacy and safety in the striped skunk (Mephitis mephitis) by the oral and intranasal routes. The SAD-B19 and ERA/BHK-21 vaccines were given orally; all three vaccines were given intranasally. Oral administration of SAD-B19 and ERA/BHK-21 vaccines induced neither seroconversion nor significant protection against rabies challenge. One skunk which consumed a SAD-B19 vaccine-laden bait succumbed to vaccine-induced rabies. Intranasal instillation of the three vaccines resulted in the deaths of two of six (AZA 2), three of six (ERA/BHK-21) and six of six (SAD-B19) skunks.