DISTRIBUTION OF SOME STEROID SULPHOKINASES IN FOETAL HUMAN TISSUES

ABSTRACT A study of the pattern of various steroid sulphokinases and phenol sulphokinase in human foetal adrenals, cerebrum, choroid plexus, heart muscle, jejunum, kidneys, liver, lungs, skeletal muscle, skin and thymus has been undertaken, using 35S-labelled 3′-phosphoadenosine-5′-phosphosulphate (...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 52; no. 4; pp. 607 - 618
Main Author Wengle, B
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1966
Subjects
Androgens - metabolism
Autoradiography
Chromatography, Paper
Dehydroepiandrosterone - metabolism
Desoxycorticosterone - metabolism
Estrogens - metabolism
Estrone - metabolism
Female
Fetus - enzymology
Humans
Phenols - metabolism
Pregnancy
Sulfur Isotopes - analysis
Tissue Extracts
Transferases - metabolism
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Summary:ABSTRACT A study of the pattern of various steroid sulphokinases and phenol sulphokinase in human foetal adrenals, cerebrum, choroid plexus, heart muscle, jejunum, kidneys, liver, lungs, skeletal muscle, skin and thymus has been undertaken, using 35S-labelled 3′-phosphoadenosine-5′-phosphosulphate (PAPS). Oestrone sulphokinase is present in all the foetal tissues studied, except the cerebrum. Significant amounts of steroid alcohol sulphokinases (e. g. DHA and DOC sulphokinase) are detected in the adrenals, jejunum, kidneys and liver. Phenol sulphokinase is also present in these tissues, as well as in the lungs. A qualitative similarity is observed between the adrenals, jejunum and liver with regard to the pattern of steroid alcohol sulphokinases, although the adrenals are a much richer source of these enzymes than the two last-mentioned organs. The activity of DOC sulphokinase is equal to, or slightly higher than, that of DHA sulphokinase in the kidney preparations, in contrast to all other human tissues containing steroid sulphokinases. Some physiological implications of these results are discussed.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0520607