Differential expression of cyclooxygenase 2 in human colorectal cancer

• Published in: Gut Vol. 47; no. 1; p. 154
• Main Authors: HULL, M, LANGMAN, M
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.2000; BMJ Publishing Group LTD
• Subjects: Adenocarcinoma - metabolism; Colorectal cancer; Colorectal Neoplasms - metabolism; Cyclooxygenase 2; Humans; Isoenzymes - biosynthesis; Letters to the Editor; Membrane Proteins; Mutation; Neoplasm Proteins - metabolism; Prostaglandin-Endoperoxide Synthases - biosynthesis; Protein expression; Proteins; Rodents; Surgery; Tumors
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.47.1.154

[...]only one of three APC/β-catenin mutated colon tumours revealed COX-2 protein induction and among the remaining 15 non-mutated tumours, two displayed COX-2 protein upregulation. [...]the fraction of APC/β-catenin mutated tumours was also slightly lower (21/38-55%) than previously reported and in accordance with the differential COX-2 induction observed. Regulation of COX-2 is not fully understood. Because of the close correlation of upregulated COX-2 with mutations in APC/β-catenin genes it has been hypothesised that there is a regulatory link and that the chemopreventive effect of NSAIDs can be attributed to inhibition of COX-2.