Differential expression of cyclooxygenase 2 in human colorectal cancer
[...]only one of three APC/β-catenin mutated colon tumours revealed COX-2 protein induction and among the remaining 15 non-mutated tumours, two displayed COX-2 protein upregulation. [...]the fraction of APC/β-catenin mutated tumours was also slightly lower (21/38-55%) than previously reported and...
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Published in | Gut Vol. 47; no. 1; p. 154 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.07.2000
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | [...]only one of three APC/β-catenin mutated colon tumours revealed COX-2 protein induction and among the remaining 15 non-mutated tumours, two displayed COX-2 protein upregulation. [...]the fraction of APC/β-catenin mutated tumours was also slightly lower (21/38-55%) than previously reported and in accordance with the differential COX-2 induction observed. Regulation of COX-2 is not fully understood. Because of the close correlation of upregulated COX-2 with mutations in APC/β-catenin genes it has been hypothesised that there is a regulatory link and that the chemopreventive effect of NSAIDs can be attributed to inhibition of COX-2. |
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Bibliography: | ark:/67375/NVC-6B0KW0VQ-3 local:gutjnl;47/1/154 href:gutjnl-47-154-1.pdf istex:8B484E31B2C5156DF4EFDF8EF7520B8E5C467732 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 |
ISSN: | 0017-5749 1468-3288 1458-3288 |
DOI: | 10.1136/gut.47.1.154 |