Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems

Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy-2-nonenal (HNE) with nearby amino acids and lipids represents one of the main research targets in cell physiology in the...

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Published inMini reviews in medicinal chemistry
Main Authors Vazdar, Katarina, Škulj, Sanja, Bakarić, Danijela, Margetić, Davor, Vazdar, Mario
Format Journal Article
LanguageEnglish
Published Netherlands 2021
Subjects
covalent modifications
lipid modification
reaction mechanism
protein modification
4-hydroxy-2-nonenal
model biological systems
oxidative stress
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Summary:Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy-2-nonenal (HNE) with nearby amino acids and lipids represents one of the main research targets in cell physiology in the last decades. Starting from the first synthesis of HNE in 1967, chemistry and reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in the field which are discussed with the special emphasis on revealing intricate details of numerous reaction mechanisms of HNE with lipids and amino acids, with the goal of understanding the reactivity of HNE at the molecular level.
ISSN:1875-5607
DOI:10.2174/1389557521666210105110538