Hydroxamic Acids Derivatives: Greener Synthesis, Antiureolytic Properties and Potential Medicinal Chemistry Applications - A Concise Review

• Published in: Current topics in medicinal chemistry Vol. 25; no. 1; p. 141
• Main Authors: Viana, Luciana P S, Pinheiro, Luan R, Petrillo, Lorenzo W, Medeiros, Isabela G, Rizo, Taina G, Modolo, Luzia V, da Silva, Cleiton M, de Fatima, Ângelo
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2025
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Chemistry, Pharmaceutical; Green Chemistry Technology; Helicobacter pylori - drug effects; Humans; Hydroxamic Acids - chemical synthesis; Hydroxamic Acids - chemistry; Hydroxamic Acids - pharmacology; Molecular Structure; Proteus mirabilis - drug effects; Urease - antagonists & inhibitors; Urease - metabolism; Urease inhibitors; Hydroxamic acids; Microorganisms; Greener synthesis; Helicobacter pylori; Medicinal applications
• ISSN: 1873-4294
• DOI: 10.2174/0115680266322401241021073138

Hydroxamic acids (HAs) are chemical compounds characterized by the general structure RCONR'OH, where R and R' can denote hydrogen, aryl, or alkyl groups. Recognized for their exceptional chelating capabilities, HAs can form mono or bidentate complexes through oxygen and nitrogen atoms, rendering them remarkably versatile. These distinctive structural attributes have paved the way for a broad spectrum of medicinal applications for HAs, among which their pivotal role as inhibitors of essential Ni(II) and Zn(II)-containing metalloenzymes. In 1962, a significant breakthrough occurred when Kobashi and colleagues identified hydroxamic acids (HAs) as potent urease inhibitors. Subsequent research has increasingly underscored their capability in combatting infections induced by ureolytic microorganisms, including and . However, comprehensive reviews exploring their potential applications in treating infections caused by ureolytic microorganisms remain scarce in the scientific literature. Thus, this minireview aims to bridge this gap by offering a systematic exploration of the subject. Furthermore, it seeks to explore the significant advancements in obtaining hydroxamic acid derivatives through environmentally sustainable methodologies.