Single-centre comparative study of in vitro fertilisation and naturally conceived babies in Indonesia

• Published in: BMJ paediatrics open Vol. 9; no. 1; p. e003142
• Main Authors: Marsubrin, Putri Maharani Tristanita, Sugiyarto, Kanya Lalitya Jayanimitta, Oswari, Jessica Sylvania, Rohsiswatmo, Rinawati, Roeslani, Rosalina Dewi, Iskandar, Adhi Teguh Perma, Sukarja, Distyayu, Sjahrullah, Muhamad Azharry Rully, Kautsar, Ahmad, Muharam, Raden
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 06.03.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Birth weight; Cesarean section; Confounding (Statistics); Developing countries; Embryos; Female; Fertilization in Vitro - adverse effects; Fertilization in Vitro - statistics & numerical data; Fetuses; Gestational age; Humans; Hypoglycemia; Hypothermia; In vitro fertilization; Indonesia - epidemiology; Infant, Newborn; Intensive care; Intensive Care Units, Neonatal - statistics & numerical data; LDCs; Length of stay; Length of Stay - statistics & numerical data; Male; Medical records; Morbidity; Neonatology; Newborn babies; Pregnancy; Pregnancy Outcome - epidemiology; Pregnancy, Multiple - statistics & numerical data; Premature babies; Premature birth; Premature Birth - epidemiology; Retrospective Studies; Sepsis; Statistical analysis; Variables; Indonesia; Neonatology
• ISSN: 2399-9772; 2399-9772
• DOI: 10.1136/bmjpo-2024-003142

BackgroundIn vitro fertilisation (IVF) offers a solution for infertility but poses increased obstetrical and perinatal risks, including higher rates of preterm birth, low birth weight and congenital anomalies. Particularly, IVF-related multiple pregnancies face significantly higher risks for preterm birth and prolonged hospital stays. This study compares neonatal outcomes between IVF and natural conception, as well as between singleton and IVF-related multiple pregnancies over the past decade.MethodThis retrospective study reviewed the medical records of babies born at Cipto Mangunkusumo Kencana Hospital from 2013 to 2023. Neonatal morbidities (hypothermia, hypoglycaemia, respiratory distress, circulation problems, sepsis, congenital anomalies, all stages of intraventricular haemorrhage and retinopathy of prematurity of all babies, neonatal intensive care unit (NICU) admission and length of stay) were dependent variables, with the mode of conception as the independent variable.ResultOf 609 subjects, 169 were IVF conceptions and 435 natural conceptions. The IVF group had higher rates of prematurity (27.8% vs 10.8%, p<0.001), multiple conceptions (37.9% vs 7.4%, p<0.001) and older maternal age (35 vs 30 years, p<0.001). Prematurity in the IVF group had an increased rate of respiratory distress (18.9% vs 12.6%, p=0.05), higher NICU admission rates (13.6% vs 3.2%, p<0.001) and longer hospital stays.ConclusionIVF pregnancies had higher risks of prematurity and respiratory distress, necessitating personalised antenatal care and close monitoring to optimise neonatal outcomes.