Adipophilin: roles in physiology and pathology

Adipophilin (ADRP/ADPH/PLIN2), an adipocyte differentiation-related protein, is highly expressed at a very early time during the differentiation of adipocytes. It assists in the formation and maintenance of intracellular lipid droplets and plays a role in regulating the physiological functions of th...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 76; no. 2; pp. 98 - 102
Main Authors Li, Feng-Zeng, Fang, Sheng
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.02.2023
BMJ Publishing Group LTD
Subjects
Adipocytes
Autophagy
Cells
Cytoplasm
Disease
Electron microscopes
Fatty acids
Glucose
Histology
Humans
Hypoxia
Kidney cancer
Lipid Metabolism
Lipids
Medical prognosis
Membrane Proteins
Metabolism
Metastasis
Molecules in pathogenesis
pathology, molecular
pathology, surgical
Perilipin-2 - metabolism
Physiology
Proteins
Roles
skin diseases
Tumors
pathology, molecular
skin diseases
pathology, surgical
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Summary:Adipophilin (ADRP/ADPH/PLIN2), an adipocyte differentiation-related protein, is highly expressed at a very early time during the differentiation of adipocytes. It assists in the formation and maintenance of intracellular lipid droplets and plays a role in regulating the physiological functions of the body. More and more studies indicate that it is involved in the occurrence and development of a variety of glycolipid metabolic diseases and tumours. In this review, we comprehensively stated the expression and functions of adipophilin and introduced its roles in physiology and pathology.
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ISSN:0021-9746
1472-4146
1472-4146
DOI:10.1136/jcp-2022-208677