Efficacy and Safety of Thrombolysis in COVID-19 Related ARDS

• Published in: Recent advances in anti-infective drug discovery Vol. 18; no. 3; p. 197
• Main Authors: Goyal, Abhishek, Niwariya, Yogesh, Pawar, Neeraj, Khurana, Alkesh, Chaudhary, Poonam
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2023
• Subjects: COVID-19 - complications; Humans; Oxygen; Respiratory Distress Syndrome - drug therapy; Retrospective Studies; SARS-CoV-2; Thrombolytic Therapy - adverse effects; COVID-19; streptokinase; tissue plasminogen activator (tPA); tenecteplase (TNK); coagulopathy; Thrombolysis; acute respiratory distress syndrome (ARDS)
• ISSN: 2772-4352
• DOI: 10.2174/2772434417666221012111042

COVID-19 causes significant pulmonary microthrombi in some individuals, leading to ARDS and death. Thrombolysis could be an effective approach in some patients with severe ARDS. We describe our experience with the usage of thrombolytic agents in critically ill COVID-19 patients who were in worsening respiratory failure. Retrospective chart analysis was done in patients who were thrombolysed between May 2020-Sept 2020. Analysis was done to find out factors associated with improvement in oxygenation and survival. Twenty-seven patients with severe ARDS [all had respiratory rate >30, FiO2 >0.6 (on NIV/HFNC) and PiO2/FiO2 ratio <120] were thrombolysed in our ICU for COVID19 causes. C.T. Pulmonary Angiography could not be done in any of the 27 patients due to poor general condition, but 2D echo was normal in most (5 had dilated RA, RV), and none of the patients was in shock. So, there was no conventional indication of thrombolysis in these patients, yet after thrombolysis, we observed dramatic changes in oxygenation (defined by a decrease in FiO2 by ≥0.2) in twenty patients. Five patients had a major bleed. Eleven patients survived (survival rate of 40.7%) and the survival rate was high {66% (8/12)} in patients who were thrombolysed within 2 days of oxygen requirement. In this unprecedented pandemic with high mortality rates, efficacy of early thrombolysis needs to be further explored in randomised controlled trials.