Moving towards establishing centres of excellence in cardiac amyloidosis: an International Cardio-Oncology Society statement

• Published in: Heart (British Cardiac Society) Vol. 110; no. 12; pp. 823 - 830
• Main Authors: Cheng, Richard, Kittleson, Michelle M, Wechalekar, Ashutosh D, Alvarez-Cardona, Jose, Mitchell, Joshua D, Scarlatelli Macedo, Ariane Vieira, Dutra, Joao Pedro Passos, Campbell, Courtney M, Liu, Jennifer E, Landau, Heather J, Davis, Margot K, Morrissey, Siobhain, Casselli, Stephen, Lousada, Isabelle, Seabra-Garcez, Juliane Dantas, Szor, Roberta Shcolnik, Ganatra, Sarju, Trachtenberg, Barry, Maurer, Mathew S, Stockerl-Goldstein, Keith, Lenihan, Daniel
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.06.2024; BMJ Publishing Group LTD
• Subjects: Amyloidosis; Biopsy; Bone marrow; Cardiology; Cardiomyopathy; Cardiomyopathy, Restrictive; Clinical trials; Genetic testing; Heart Failure; Hematology; Immunology; Liver transplants; Mass spectrometry; Nephrology; Neurology; Oncology; Ophthalmology; Proteins; Pulmonology; Review; Rheumatology; Scientific imaging; Scintigraphy; Stem cell transplantation; Working groups; United Kingdom > UK; United States > US; Italy; Heart Failure; Cardiomyopathy, Restrictive
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/heartjnl-2023-323502

The prevalence of amyloidosis has been increasing, driven by a combination of improved awareness, evolution of diagnostic pathways, and effective treatment options for both transthyretin and light chain amyloidosis. Due to the complexity of amyloidosis, centralised expert providers with experience in delineating the nuances of confirmatory diagnosis and management may be beneficial. There are many potential benefits of a centre of excellence designation for the treatment of amyloidosis including recognition of institutions that have been leading the way for the optimal treatment of this condition, establishing the expectations for any centre who is engaging in the treatment of amyloidosis and developing cooperative groups to allow more effective research in this disease space. Standardising the expectations and criteria for these centres is essential for ensuring the highest quality of clinical care and community education. In order to define what components are necessary for an effective centre of excellence for the treatment of amyloidosis, we prepared a survey in cooperation with a multidisciplinary panel of amyloidosis experts representing an international consortium. The purpose of this position statement is to identify the essential elements necessary for highly effective clinical care and to develop a general standard with which practices or institutions could be recognised as a centre of excellence.