Unravelling the neutrophil enigma: a new insight into RSV-induced bronchiolitis in infants

Correspondence to Dr Aaron Scott, Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; a.scott@bham.ac.uk In this issue of Thorax, Robinson et al describe a novel in vitro model of respiratory syncytial virus (RSV) infection to assess neonatal an...

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Bibliographic Details
Published inThorax Vol. 79; no. 6; pp. 487 - 488
Main Authors Grudzinska, Frances Susanna, Scott, Aaron
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and British Thoracic Society 01.06.2024
BMJ Publishing Group LTD
Subjects
Adults
Apoptosis
Bronchiolitis - virology
Bronchiolitis, Viral - complications
Editorial
Humans
Immunization
Infant
Infections
Inflammation
Lavage
Neutrophil Biology
Neutrophils
Older people
Paediatric Lung Disaese
Pathogenesis
Pathogens
Premature babies
Premature birth
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - complications
Thorax
Viral infection
United Kingdom > UK
Viral infection
Neutrophil Biology
Paediatric Lung Disaese
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Summary:Correspondence to Dr Aaron Scott, Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; a.scott@bham.ac.uk In this issue of Thorax, Robinson et al describe a novel in vitro model of respiratory syncytial virus (RSV) infection to assess neonatal and adult neutrophil responses.1 The focus was on observing neutrophil migration across RSV-infected differentiated human nasal airway epithelial cells (AECs) in a basolateral to apical direction—mimicking the progression to the airway lumen. The difference between neutrophils from adults, premature infants and term infants has been widely reported, in addition, mode of delivery is known to impact neonatal neutrophil function.4 To minimise these factors, the authors used cord blood from term neonates delivered by elective caesarean section. [...]the temporal nature of neutrophil influx and apoptosis should be explored further, in animal models of respiratory infection depletion of neutrophils after the peak influx results in better outcomes suggesting that the optimal neutrophil response is time bound. Funding This study was funded by Asthma and Lung UK (MCFPHD20F\2) Dunhill Medical Trust (RTF1906\86) Health Technology Assessment Programme (NIHR129593) Efficacy and Mechanism Evaluation Programme (NIHR131600) Medical Research Council (MR/S002782/1).
Bibliography:SourceType-Other Sources-1
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ISSN:0040-6376
1468-3296
DOI:10.1136/thorax-2023-221130