Bibliometric Analysis and Systemic Review of Cantharidin Research Worldwide

• Published in: Current pharmaceutical biotechnology Vol. 25; no. 12; p. 1585
• Main Authors: He, Tianmu, Duan, Cancan, Feng, Wenzhong, Ao, Jingwen, Lu, Dingyang, Li, Xiaofei, Zhang, Jianyong
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Bibliometrics; Cantharidin - therapeutic use; Humans; Protein Phosphatase 2 - antagonists & inhibitors; Protein Phosphatase 2 - metabolism; toxic mechanism; protein phosphatase 2A; pharmacology; Bibliometric; surgical resection; hepatocellular carcinoma; cantharidin
• ISSN: 1873-4316
• DOI: 10.2174/0113892010244101231024111850

Cantharidin (CTD), a natural toxic compound from blister beetle Mylabris, has been used for cancer treatment for millenary. CTD and its analogs have become mainstream adjuvant drugs with radiotherapy and chemotherapy in clinical applications. However, the detailed pharmacology mechanism of CTD was not fully elucidated. Publications of CTD were collected from the Web of Science Core Collection database from 1991 to 2023 using CiteSpace, VOSviewer, and Scimago Graphica software. A total of 1,611 publications of CTD were mainly published in China and the United States. The University of Newcastle has published the most researches. Mcclusey, Adam, Sakoff, Jennette, and Zhang, Yalin had the most CTD publications with higher H. Notably, CTD researches were mainly published in . Cluster profile results revealed that protein phosphatase 2A (PP2A), human gallbladder carcinoma, Aidi injection, and cell apoptosis were the hotspots. Concentration on the pharmacology function of PP2A subunit regulation, hepatotoxicity, nephrotoxicity, and cardiotoxicity mechanism should be strengthened in the future. Bibliometric analysis combined with a systemic review of CTD research first revealed that PP2A and CTD analogs were the knowledge base of CTD, and PP2A subunit regulation and toxic mechanism could be the frontiers of CTD.