Engineering Platelet Membrane Imitating Nanoparticles for Targeted Therapeutic Delivery

• Published in: Current pharmaceutical biotechnology Vol. 25; no. 10; p. 1230
• Main Authors: Adhalrao, Shradha B, Jadhav, Kisan R, Patil, Prashant L, Kadam, Vilasrao J, Nirmal, M Kasekar
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Animals; Blood Platelets - metabolism; Cell Membrane - metabolism; Drug Delivery Systems - methods; Humans; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Platelet membrane; mimicking; phototherapy; nanoparticles; therapeutic delivery; imitating
• ISSN: 1873-4316
• DOI: 10.2174/1389201024666230804140926

Platelet Membrane Imitating Nanoparticles (PMINs) is a novel drug delivery system that imitates the structure and functionality of platelet membranes. PMINs imitate surface markers of platelets to target specific cells and transport therapeutic cargo. PMINs are engineered by incorporating the drug into the platelet membrane and encapsulating it in a nanoparticle scaffold. This allows PMINs to circulate in the bloodstream and bind to target cells with high specificity, reducing off-target effects and improving therapeutic efficacy. The engineering of PMINs entails several stages, including the separation and purification of platelet membranes, the integration of therapeutic cargo into the membrane, and the encapsulation of the membrane in a nanoparticle scaffold. In addition to being involved in a few pathological conditions including cancer, atherosclerosis, and rheumatoid arthritis, platelets are crucial to the body's physiological processes. This study includes the preparation and characterization of platelet membrane-like nanoparticles and focuses on their most recent advancements in targeted therapy for conditions, including cancer, immunological disorders, atherosclerosis, phototherapy, etc. PMINs are a potential drug delivery system that combines the advantages of platelet membranes with nanoparticles. The capacity to create PMMNs with particular therapeutic cargo and surface markers provides new possibilities for targeted medication administration and might completely change the way that medicine is practiced. Despite the need for more studies to optimize the engineering process and evaluate the effectiveness and safety of PMINs in clinical trials, this technology has a lot of potential.