The soluble sperm factor that activates the egg: PLCzeta and beyond
PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+...
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Published in | Reproduction (Cambridge, England) Vol. 160; no. 1; pp. V9 - V11 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Bioscientifica Ltd
01.07.2020
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Subjects | |
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Abstract | PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs. |
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AbstractList | PLCzeta(ζ) initiates Ca
2+
oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca
2+
release. Here, I propose a hypothesis for how this second sperm factor might cause Ca
2+
oscillations in mouse eggs. PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs. |
Author | Swann, Karl |
AuthorAffiliation | School of Biosciences, Cardiff University, Cardiff, UK |
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CitedBy_id | crossref_primary_10_3390_ijms21239179 crossref_primary_10_1093_humrep_deae078 crossref_primary_10_1111_and_14269 crossref_primary_10_1016_j_theriogenology_2022_06_018 crossref_primary_10_1093_biolre_ioac037 crossref_primary_10_1186_s13578_020_00520_1 crossref_primary_10_1093_hropen_hoac003 crossref_primary_10_3389_fcell_2023_1193248 |
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Snippet | PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply... PLCzeta(ζ) initiates Ca 2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply... |
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Title | The soluble sperm factor that activates the egg: PLCzeta and beyond |
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