The soluble sperm factor that activates the egg: PLCzeta and beyond

PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+...

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Published inReproduction (Cambridge, England) Vol. 160; no. 1; pp. V9 - V11
Main Author Swann, Karl
Format Journal Article
LanguageEnglish
Published Bioscientifica Ltd 01.07.2020
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Abstract PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.
AbstractList PLCzeta(ζ) initiates Ca 2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca 2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca 2+ oscillations in mouse eggs.
PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.
Author Swann, Karl
AuthorAffiliation School of Biosciences, Cardiff University, Cardiff, UK
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CitedBy_id crossref_primary_10_3390_ijms21239179
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Snippet PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply...
PLCzeta(ζ) initiates Ca 2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply...
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Title The soluble sperm factor that activates the egg: PLCzeta and beyond
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