The soluble sperm factor that activates the egg: PLCzeta and beyond
PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+...
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Published in | Reproduction (Cambridge, England) Vol. 160; no. 1; pp. V9 - V11 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Bioscientifica Ltd
01.07.2020
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Subjects | |
Online Access | Get full text |
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Summary: | PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1470-1626 1741-7899 |
DOI: | 10.1530/REP-20-0079 |