The soluble sperm factor that activates the egg: PLCzeta and beyond

PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+...

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Published inReproduction (Cambridge, England) Vol. 160; no. 1; pp. V9 - V11
Main Author Swann, Karl
Format Journal Article
LanguageEnglish
Published Bioscientifica Ltd 01.07.2020
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Summary:PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1470-1626
1741-7899
DOI:10.1530/REP-20-0079