The Role of MicroRNAs, CircRNAs, and LncRNAs in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) constitutes a heterogeneous hematological malignancy, often correlated with disruptions in various signaling pathways, chromosomal deletions, and gene mutations. A comprehensive grasp of CLL pathogenesis and its associated risk factors remains vital for the develop...

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Bibliographic Details
Published inCurrent pharmaceutical design
Main Authors Chen, Nan, Zhang, Yaping, Jiang, Yongning, Gao, Guangcan, Li, Jianyong, Shi, Wenyu
Format Journal Article
LanguageEnglish
Published United Arab Emirates 25.04.2025
Subjects
Chronic lymphocytic leukemia
signaling pathways
prognostic markers
target genes
non-coding RNAs
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Summary:Chronic lymphocytic leukemia (CLL) constitutes a heterogeneous hematological malignancy, often correlated with disruptions in various signaling pathways, chromosomal deletions, and gene mutations. A comprehensive grasp of CLL pathogenesis and its associated risk factors remains vital for the development of more efficacious treatment strategies. Although non-coding RNAs (ncRNAs) do not encode proteins, they possess substantial regulatory influence over target genes. These ncRNAs govern a multitude of target genes implicated in the pathogenesis of CLL. Furthermore, some ncRNAs serve as prognostic markers in CLL and might contribute to overcoming chemotherapy resistance. This review determines the association between ncRNAs and the molecular mechanisms driving the onset and advancement of CLL, with particular emphasis on the roles of these ncRNAs in modulating signaling pathways, encompassing NF-κB/PI3K-AKT/TNF and P53 in CLL. It also underscores their relevance as significant biomarkers and their potential as therapeutic targets in clinical CLL settings.
ISSN:1873-4286
DOI:10.2174/0113816128361848250401200001