Pharmacokinetics of a single oral administration of cefalexin in mares and foals

• Published in: Veterinary record Vol. 168; no. 16; p. 431
• Main Authors: Ladaga, G. J. B., Lezica, F. P., Barboni, A. M., Picos, J. A., de Erausquin, G. A.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Limited 23.04.2011; Blackwell Publishing Ltd
• Subjects: Administration, Oral; Animals; Animals, Newborn - metabolism; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Bioavailability; Cephalexin - pharmacokinetics; Female; Half-Life; Horses; Horses - metabolism; Plasma
• ISSN: 0042-4900; 2042-7670
• DOI: 10.1136/vr.c6403

The mean (sd) time at which the plasma concentration exceeded 4 µg/ml was 3.6 (0.4) hours in mares and 4.9 (0.5) hours in foals, whereas the mean time at which the concentration exceeded 2 µg/ml was 4.4 (0.6) hours in mares and 5.9 (0.4) hours in foals. [...]an oral dose of 30 mg/kg cefalexin resulted in plasma concentrations above the minimum inhibitory concentration (MIC) for more than four hours in both mares and foals ( Fig 1c ). Oral cefadroxil absorption decreases with age without increasing bioavailability ( Duffee and others 1997 ), possibly due to its solubility in lipids and the increased body fat that results from ageing. [...]oral cefadroxil is absorbed in foals but not in horses ( Wilson and others 1985 ).