Aggressive Management of Intra-arterial Temazepam Injection

Intravenous injection of the oral formulation of Temazepam is a common form of drug abuse. At the request of the Home Office, manufacturers have developed solid dose forms to replace the liquid filled capsules, but a number of cases of accidental intra-arterial injection of the new formulation have...

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Bibliographic Details
Published inBMJ military health Vol. 140; no. 2; pp. 93 - 94
Main Authors Russell, I D, Kane, G G, Royle, C A J P, Jackson, D S
Format Journal Article
LanguageEnglish
Published London Regimental Headquarters RAMC 01.06.1994
BMJ Publishing Group LTD
Subjects
Adult
Biological and medical sciences
Brachial Artery
Chemistry, Pharmaceutical
Compartment Syndromes - chemically induced
Drug addictions
Epoprostenol - therapeutic use
Humans
Injections, Intra-Arterial - adverse effects
Male
Medical sciences
Nifedipine - therapeutic use
Platelet Aggregation Inhibitors - therapeutic use
Salvage Therapy
Substance Abuse, Intravenous - complications
Substance Abuse, Intravenous - therapy
Temazepam
Toxicology
Vasodilator Agents - therapeutic use
Human
Drug addiction
Toxicity
Acute
Case study
Colloidal gel
Chemotherapy
Ischemia
Surgery
Dosage form
Benzodiazepine derivatives
Upper limb
Combined treatment
Intraarterial administration
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Summary:Intravenous injection of the oral formulation of Temazepam is a common form of drug abuse. At the request of the Home Office, manufacturers have developed solid dose forms to replace the liquid filled capsules, but a number of cases of accidental intra-arterial injection of the new formulation have been reported, with varying management strategies advocated. A case is presented where prompt aggressive management using surgical and pharmacological measures resulted in complete limb salvage. Previous reported cases and management options are discussed.
ISSN:0035-8665
2633-3767
2052-0468
2633-3775
DOI:10.1136/jramc-140-02-09