DEPIGMENTATION IN RANA TEMPORARIA TADPOLES AS A RESULT OF METHYLTHIOURACIL TREATMENT

The aim of this study originally was to elucidate whether methylthiouracil will cause thyroid hyperplasia and inhibition of metamorphosis in frog tadpoles or not, provided it should prove to be sufficiently non-toxic to be employed experimentally. During the experiments, however, changes in the pigm...

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Bibliographic Details
Published inJournal of endocrinology Vol. 6; no. 1; pp. 23 - 27
Main Author BLACKSTAD, T W
Format Journal Article
LanguageEnglish
Published England 01.04.1949
Subjects
Animals
Larva
Methylthiouracil
Old Medline
Rana temporaria
Thiourea - pharmacology
THIOUREA/effects
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Summary:The aim of this study originally was to elucidate whether methylthiouracil will cause thyroid hyperplasia and inhibition of metamorphosis in frog tadpoles or not, provided it should prove to be sufficiently non-toxic to be employed experimentally. During the experiments, however, changes in the pigmentation of the larvae also occurred, and it is these observations which are chiefly described in this communication. A study of the literature revealed some communications on related experiments. On the whole agreement exists that most of the substances which are known to be goitrogenic in mammals have the same effect in amphibian larvae [Gordon, Goldsmith & Charipper, 1943; 1945]. However, changes in pigmentation after such treatment are mentioned only by Lynn & De Marie [1946]. These investigators noted inhibition of metamorphosis in Rana sylvatica immersed into 0·05 % thiourea and thiouracil. Animals treated with thiourea did not develop further when reimmersed in water. From the 26th day
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0060023