BREAKDOWN OF [3H]OXYTOCIN BY RAT TISSUES IN VITRO

Tissue uptake of oxytocin by rat mammary gland, uterus, heart and skeletal muscle was demonstrated by incubation of these tissues with 3H-labelled oxytocin. Chromatography of tissue extracts showed that some breakdown of oxytocin had occurred after only 30 s. However, in all cases there was no break...

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Bibliographic Details
Published inJournal of endocrinology Vol. 59; no. 2; pp. 305 - 312
Main Authors Egan, S M, Livingston, A
Format Journal Article
LanguageEnglish
Published England BioScientifica 01.11.1973
Subjects
Animals
Biological Assay
Chromatography
Female
In Vitro Techniques
Male
Mammary Glands, Animal - metabolism
Muscles - metabolism
Myocardium - metabolism
Oxytocin - metabolism
Rats
Tritium
Uterus - metabolism
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Summary:Tissue uptake of oxytocin by rat mammary gland, uterus, heart and skeletal muscle was demonstrated by incubation of these tissues with 3H-labelled oxytocin. Chromatography of tissue extracts showed that some breakdown of oxytocin had occurred after only 30 s. However, in all cases there was no breakdown of oxytocin in the corresponding incubation medium. This indicated that the breakdown of oxytocin occurred within the tissues.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0590305