OVULATION INDUCED BY SYNTHETIC LUTEINIZING HORMONE RELEASING FACTOR IN ANDROGEN-STERILIZED FEMALE RATS

It is well known that administration of a single injection of testosterone propionate to newborn female rats results in permanent anovulatory sterility. After puberty these animals show permanent vaginal cornification and their ovaries contain follicles but no corpora lutea (Barraclough, 1961). One...

Full description

Saved in:
Bibliographic Details
Published inJournal of endocrinology Vol. 55; no. 1; pp. 207 - 208
Main Authors Borvendég, J, Hermann, H, Bajusz, S
Format Journal Article
LanguageEnglish
Published England 01.10.1972
Subjects
Animals
Animals, Newborn
Disease Models, Animal
Female
Infertility, Female - chemically induced
Luteinizing Hormone
Ovulation - drug effects
Pituitary Hormone-Releasing Hormones - pharmacology
Pituitary Hormone-Releasing Hormones - therapeutic use
Polycystic Ovary Syndrome - drug therapy
Rats
SHORT COMMUNICATIONS
Testosterone
Online AccessGet full text

Cover

More Information
Summary:It is well known that administration of a single injection of testosterone propionate to newborn female rats results in permanent anovulatory sterility. After puberty these animals show permanent vaginal cornification and their ovaries contain follicles but no corpora lutea (Barraclough, 1961). One of the most important lesions in these rats seems to be a blockade of the pre-ovulatory discharge of luteinizing hormone releasing factor (LH-RF) from the median eminence. Porcine LH-RF has been shown to be a decapeptide, pyro Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly(NH2), and when this polypeptide was synthesized it was found to have follicle-stimulating hormone releasing factor activity as well (Matsuo, Arimura, Nair & Schally, 1971; Matsuo, Baba, Nair, Arimura & Schally, 1971). In the present experiments we posed the question of whether a subcutaneous injection of synthetic LH-RF could induce ovulation in androgen-sterilized female rats, and if so, whether this would be a dose-dependent effect. Albino rats of the Sprague—Dawley
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0550207