Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions

A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials-catal...

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Bibliographic Details
Published inLetters in organic chemistry Vol. 17; no. 11; pp. 832 - 836
Main Authors Nematpour, Manijeh, Dastjerdi, Hossein Fasihi, Jahani, Mehdi, Tabatabai, Sayyed Abbas
Format Journal Article
LanguageEnglish
Published SHARJAH Bentham Science Publ Ltd 01.01.2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
isocyanides
PROQUAZONE
quinazoline-2,4(1H,3H)-diones
EFFICACY
C-H Activation
isocyanate
BOND FUNCTIONALIZATION
aniline
DERIVATIVES
Cu-catalyzed
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Summary:A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials-catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically (H-1- and C-13-NMR, IR and El-MS) and by elemental analyses.
ISSN:1570-1786
1875-6255
DOI:10.2174/1570178616666190905142545