EFFECT OF PROSTAGLANDIN E2 ON THE CONCENTRATION OF CORTISOL IN THE PLASMA OF NEWBORN LAMBS

McGlll University, Department of Obstetrics and Gynecology, Royal Victoria Hospital, Women's Pavilion, Montreal, Quebec H3A 1A1, Canada (Received 26 July 1977) Infusion of prostaglandin E2 (PGE2) into the carotid artery of the foetal lamb increases the concentration of cortisol in the foetal pl...

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Published inJournal of endocrinology Vol. 76; no. 1; pp. 177 - 178
Main Authors Challis, J R, Carson, G D, Naftolin, F
Format Journal Article
LanguageEnglish
Published England 01.01.1978
Subjects
Adrenocorticotropic Hormone - pharmacology
Animals
Animals, Newborn - blood
Hydrocortisone - blood
Prostaglandins E - pharmacology
Sheep - blood
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Summary:McGlll University, Department of Obstetrics and Gynecology, Royal Victoria Hospital, Women's Pavilion, Montreal, Quebec H3A 1A1, Canada (Received 26 July 1977) Infusion of prostaglandin E2 (PGE2) into the carotid artery of the foetal lamb increases the concentration of cortisol in the foetal plasma (Louis, Challis, Robinson & Thorburn, 1976) even at stages of pregancy when the foetal adrenal gland is relatively insensitive to endogenous or exogenous adrenocorticotrophin (ACTH; Bassett & Thorburn, 1973; Boddy, Jones, Mantell, Ratcliffe & Robinson, 1974). We have now examined the site of this prostaglandin action in lambs aged 5–6 days, by which time closure of the ductus arteriosus is advanced (see Dawes, 1968), and pulmonary metabolism should separate the effects of prostaglandins administered into the brachiocephalic trunk or descending aorta. The lambs used in this study were born spontaneously at full term. They were housed with their mothers except during experimental periods. Vascular catheterization with a
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ISSN:0022-0795
1479-6805
DOI:10.1677/joe.0.0760177