Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders

• Published in: Current medicinal chemistry
• Main Authors: Chen, Xiaoling, Lu, Ting, Zheng, Ying, Lin, Zhiyong, Liu, Chaoqi, Yuan, Ding, Yuan, Chengfu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 27.04.2024
• Subjects: signaling pathway; cancer; cell; inflammation; MiR-136-5p; bioinformatics
• ISSN: 1875-533X
• DOI: 10.2174/0109298673283936240215110627

MiR-136-5p plays a vital function in regulating developmental processes as well as in the pathophysiology of diseases, with a notable record in tumor suppression. This article summarizes the latest findings on the physiological and pathophysiological processes of miR-136-5p in diseases. We searched for relevant studies and selected research articles from the last five years on PubMed with miR-136-5p as the keyword. MiR-136-5p represents a class of microRNAs (miRNAs) that are involved in various human maladies, encompassing cancers, cardio-cerebrovascular disease, diabetes, inflammatory disease, tuberous sclerosis, idiopathic pulmonary fibrosis, and polycystic ovary syndrome. Altered expression of miR-136-5p in specific ailments results in downstream gene expression imbalance, influencing cellular behaviors, such as migration, proliferation, and invasion. Furthermore, miR-136-5p is implicated in five signaling pathways, where it is critical in the onset and advancement of a number of illnesses. Additionally, it has the potential to promote drug resistance to a variety of medications. The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.