Azurophil granules are heterogeneous with respect to mobilization induced by different concentrations of fMLP

Azurophil granules of neutrophils beyond their already known heterogeneity of beta-glucuronidase and myeloperoxidase enzyme contents are heterogeneous with respect to a spontaneous or low concentration (2.3 or 23 nM) of formyl-Met-Leu-Phe-induced mobilization. This suggests that the heterogeneity of...

Full description

Saved in:
Bibliographic Details
Published inHaematologia Vol. 31; no. 3; pp. 181 - 189
Main Authors Németh, Krisztina, Furész, József, Adorjáni, Endre, Cseko, Csongor, Lakatos, Susan, Bielik, Helga
Format Journal Article
LanguageEnglish
Published The Netherlands VSP 01.01.2001
Subjects
BETA-GLUCURONIDASE RELEASE
Calcium - pharmacology
Cell Degranulation - drug effects
Cytoplasmic Granules - drug effects
Cytoplasmic Granules - enzymology
Dose-Response Relationship, Drug
FMLP-INDUCED GRANULE MOBILIZATION
Glucuronidase - secretion
HETEROGENEITY OF AZUROPHIL GRANULES
Humans
MPO RELEASE
N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
Neutrophil Activation - drug effects
Neutrophils - enzymology
Neutrophils - ultrastructure
Peroxidase - secretion
PMNL
Online AccessGet full text

Cover

More Information
Summary:Azurophil granules of neutrophils beyond their already known heterogeneity of beta-glucuronidase and myeloperoxidase enzyme contents are heterogeneous with respect to a spontaneous or low concentration (2.3 or 23 nM) of formyl-Met-Leu-Phe-induced mobilization. This suggests that the heterogeneity of azurophil granules is manifested in their functions too.
Bibliography:href:15685594_031_03_s001_text.pdf
ark:/67375/JKT-913C4GVP-K
istex:5E10071D690E3580F93B6F26C4BAD85A9CF228CD
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0017-6559
1568-5594
DOI:10.1163/15685590152763728