Morphological changes in previously frozen formalin-fixed paraffin-embedded (FFPE) tissue

Given the above context, it may be of clinical importance for the surgical pathologist to be able to recognise freeze-induced morphological changes on routine H&E-stained sections, and to have a published reference with their description in the pathology literature. There is a substantial body o...

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Published inJournal of clinical pathology Vol. 75; no. 6; pp. 431 - 432
Main Author Fischer, Edgar G
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.06.2022
BMJ Publishing Group LTD
Subjects
Breast cancer
carcinoma
Cytoplasm
Lymphatic system
Morphology
Ovaries
Pathology
PostScript
Quality control
Stains & staining
Surgeons
surgical
Thyroid cancer
tissue fixation
Tumors
tissue fixation
surgical
pathology
carcinoma
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Abstract Given the above context, it may be of clinical importance for the surgical pathologist to be able to recognise freeze-induced morphological changes on routine H&E-stained sections, and to have a published reference with their description in the pathology literature. There is a substantial body of literature on the use of frozen sections and related quality assurance issues in surgical pathology.1–3 6 Multiple textbooks on intraoperative consultation and frozen section interpretation have been published in recent years.7–9 But, to the author’s knowledge, there are no published references that describe the morphological changes caused by prior freezing. [...]morphological changes in the cells of previously frozen tissue can be recognised as such by the trained eye of the surgical pathologist.
AbstractList Given the above context, it may be of clinical importance for the surgical pathologist to be able to recognise freeze-induced morphological changes on routine H&E-stained sections, and to have a published reference with their description in the pathology literature. There is a substantial body of literature on the use of frozen sections and related quality assurance issues in surgical pathology.1–3 6 Multiple textbooks on intraoperative consultation and frozen section interpretation have been published in recent years.7–9 But, to the author’s knowledge, there are no published references that describe the morphological changes caused by prior freezing. [...]morphological changes in the cells of previously frozen tissue can be recognised as such by the trained eye of the surgical pathologist.
Author Fischer, Edgar G
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34697031$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1097/00129039-200009000-00012
10.1093/ajcp/aqaa259
10.5858/2006-130-337-TVOMFS
10.5858/133.7.1135
10.5858/2005-129-1529-TFSPIT
10.1111/his.13756
10.1007/978-3-030-71308-9
10.1097/00022744-200009000-00012
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Copyright Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
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carcinoma
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References Lechago (R1) 2005; 129
Taxy (R2) 2009; 133
Edgerton, Roberts, Montone (R4) 2000; 8
Yoshida, Satomi, Ohno (R5) 2019; 74
Raab, Tworek, Souers (R3) 2006; 130
Laakman, Chen, Lake (R6) 2021; 156
Yoshida (2024053002290046000_75.6.431.5) 2019; 74
2024053002290046000_75.6.431.9
2024053002290046000_75.6.431.8
2024053002290046000_75.6.431.7
Lechago (2024053002290046000_75.6.431.1) 2005; 129
Taxy (2024053002290046000_75.6.431.2) 2009; 133
Laakman (2024053002290046000_75.6.431.6) 2021; 156
2024053002290046000_75.6.431.4
Raab (2024053002290046000_75.6.431.3) 2006; 130
References_xml – volume: 8
  start-page: 244
  year: 2000
  ident: R4
  article-title: Immunohistochemical performance of antibodies on previously frozen tissue
  publication-title: Appl Immunohistochem Mol Morphol
  doi: 10.1097/00129039-200009000-00012
  contributor:
    fullname: Montone
– volume: 156
  start-page: 461
  year: 2021
  ident: R6
  article-title: Frozen section quality assurance
  publication-title: Am J Clin Pathol
  doi: 10.1093/ajcp/aqaa259
  contributor:
    fullname: Lake
– volume: 130
  start-page: 337
  year: 2006
  ident: R3
  article-title: The value of monitoring frozen section-permanent section correlation data over time
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/2006-130-337-TVOMFS
  contributor:
    fullname: Souers
– volume: 133
  start-page: 1135
  year: 2009
  ident: R2
  article-title: Frozen section and the surgical pathologist: a point of view
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/133.7.1135
  contributor:
    fullname: Taxy
– volume: 129
  start-page: 1529
  year: 2005
  ident: R1
  article-title: The frozen section: pathology in the trenches
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/2005-129-1529-TFSPIT
  contributor:
    fullname: Lechago
– volume: 74
  start-page: 350
  year: 2019
  ident: R5
  article-title: Frequent false-negative immunohistochemical staining with IDH1 (R132H)-specific H09 antibody on frozen section control slides: a potential pitfall in glioma diagnosis
  publication-title: Histopathology
  doi: 10.1111/his.13756
  contributor:
    fullname: Ohno
– volume: 133
  start-page: 1135
  year: 2009
  ident: 2024053002290046000_75.6.431.2
  article-title: Frozen section and the surgical pathologist: a point of view
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/133.7.1135
  contributor:
    fullname: Taxy
– volume: 74
  start-page: 350
  year: 2019
  ident: 2024053002290046000_75.6.431.5
  article-title: Frequent false-negative immunohistochemical staining with IDH1 (R132H)-specific H09 antibody on frozen section control slides: a potential pitfall in glioma diagnosis
  publication-title: Histopathology
  doi: 10.1111/his.13756
  contributor:
    fullname: Yoshida
– volume: 156
  start-page: 461
  year: 2021
  ident: 2024053002290046000_75.6.431.6
  article-title: Frozen section quality assurance
  publication-title: Am J Clin Pathol
  doi: 10.1093/ajcp/aqaa259
  contributor:
    fullname: Laakman
– volume: 129
  start-page: 1529
  year: 2005
  ident: 2024053002290046000_75.6.431.1
  article-title: The frozen section: pathology in the trenches
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/2005-129-1529-TFSPIT
  contributor:
    fullname: Lechago
– ident: 2024053002290046000_75.6.431.7
  doi: 10.1007/978-3-030-71308-9
– ident: 2024053002290046000_75.6.431.8
– ident: 2024053002290046000_75.6.431.9
– ident: 2024053002290046000_75.6.431.4
  doi: 10.1097/00022744-200009000-00012
– volume: 130
  start-page: 337
  year: 2006
  ident: 2024053002290046000_75.6.431.3
  article-title: The value of monitoring frozen section-permanent section correlation data over time
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/2006-130-337-TVOMFS
  contributor:
    fullname: Raab
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SubjectTerms Breast cancer
carcinoma
Cytoplasm
Lymphatic system
Morphology
Ovaries
Pathology
PostScript
Quality control
Stains & staining
Surgeons
surgical
Thyroid cancer
tissue fixation
Tumors
Title Morphological changes in previously frozen formalin-fixed paraffin-embedded (FFPE) tissue
URI http://dx.doi.org/10.1136/jclinpath-2021-207922
https://www.ncbi.nlm.nih.gov/pubmed/34697031
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