Morphological changes in previously frozen formalin-fixed paraffin-embedded (FFPE) tissue

Given the above context, it may be of clinical importance for the surgical pathologist to be able to recognise freeze-induced morphological changes on routine H&E-stained sections, and to have a published reference with their description in the pathology literature. There is a substantial body o...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical pathology Vol. 75; no. 6; pp. 431 - 432
Main Author Fischer, Edgar G
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.06.2022
BMJ Publishing Group LTD
Subjects
Breast cancer
carcinoma
Cytoplasm
Lymphatic system
Morphology
Ovaries
Pathology
PostScript
Quality control
Stains & staining
Surgeons
surgical
Thyroid cancer
tissue fixation
Tumors
tissue fixation
surgical
pathology
carcinoma
Online AccessGet full text

Cover

More Information
Summary:Given the above context, it may be of clinical importance for the surgical pathologist to be able to recognise freeze-induced morphological changes on routine H&E-stained sections, and to have a published reference with their description in the pathology literature. There is a substantial body of literature on the use of frozen sections and related quality assurance issues in surgical pathology.1–3 6 Multiple textbooks on intraoperative consultation and frozen section interpretation have been published in recent years.7–9 But, to the author’s knowledge, there are no published references that describe the morphological changes caused by prior freezing. [...]morphological changes in the cells of previously frozen tissue can be recognised as such by the trained eye of the surgical pathologist.
Bibliography:Correspondence
SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0021-9746
1472-4146
DOI:10.1136/jclinpath-2021-207922