Chronic penile ulcer as the first manifestation of HIV infection

PCR analysis detected herpes simplex virus (HSV-2) in the smear from the ulcer exudate and was negative for cytomegalovirus and Epstein-Barr virus infection. In developed countries, the most frequent aetiological agents are Treponema pallidum and HSV type 1 and 2, the latter being the most frequent...

Full description

Saved in:
Bibliographic Details
Published inBMJ case reports Vol. 2017; p. bcr-2017-221604
Main Authors Kieselova, Katarina, Santiago, Felicidade, Falhas, Carina, Henrique, Martinha
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 07.08.2017
BMJ Publishing Group
Subjects
Acquired immune deficiency syndrome
Acyclovir - analogs & derivatives
Acyclovir - therapeutic use
AIDS
Anti-HIV Agents - therapeutic use
Antiviral Agents - therapeutic use
Case reports
Chronic Disease
Family medical history
Herpes viruses
HIV
HIV Infections - diagnosis
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus
Humans
Images In
Infections
Infectious diseases
Male
Penile Diseases - drug therapy
Penile Diseases - virology
Sexually transmitted diseases
Skin Ulcer - virology
STD
Ulcers
Valacyclovir
Valine - analogs & derivatives
Valine - therapeutic use
Young Adult
HIV/AIDS
herpes simplex virus
dermatology
Online AccessGet full text

Cover

More Information
Summary:PCR analysis detected herpes simplex virus (HSV-2) in the smear from the ulcer exudate and was negative for cytomegalovirus and Epstein-Barr virus infection. In developed countries, the most frequent aetiological agents are Treponema pallidum and HSV type 1 and 2, the latter being the most frequent cause in HIV-infected patients. 1 In this group, the natural course of genital herpes lesions may be altered, presenting as a chronic extensive ulcer, hypertrophic or tumour-like lesions. 2 Learning points Chronic genital ulcers with duration with >1month are the hallmark of the immunocompromised status of the patient and should promptly lead to HIV testing Presence of genital herpes lesions has been shown to increase HIV transmission, and, additionally, is associated with elevated HIV viral load and the disease progression in affected individuals. 3 Contributors: FS and KK: made the diagnosis and performed the complete investigation and management of the patient.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2017-221604