An Insight into Vital Genes Responsible for β-cell Formation

The regulation of glucose homeostasis and insulin secretion by pancreatic β-cells, when disturbed, will result in diabetes mellitus. Replacement of dysfunctional or lost β-cells with fully functional ones can tackle the problem of β-cell generation in diabetes mellitus. Various pancreatic-specific g...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1450; p. 1
Main Authors Narayan, Gloria, Ronima K R, Agrawal, Akriti, Thummer, Rajkumar P
Format Journal Article
LanguageEnglish
Published United States 2024
Subjects
Cell Differentiation - genetics
Diabetes Mellitus
Humans
Insulin
Insulin-Secreting Cells
Pancreas
Pluripotent Stem Cells
Transcription factors
Pancreas
β-cells
Diabetes mellitus
Genes
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Summary:The regulation of glucose homeostasis and insulin secretion by pancreatic β-cells, when disturbed, will result in diabetes mellitus. Replacement of dysfunctional or lost β-cells with fully functional ones can tackle the problem of β-cell generation in diabetes mellitus. Various pancreatic-specific genes are expressed during different stages of development, which have essential roles in pancreatogenesis and β-cell formation. These factors play a critical role in cellular-based studies like transdifferentiation or de-differentiation of somatic cells to multipotent or pluripotent stem cells and their differentiation into functional β-cells. This work gives an overview of crucial transcription factors expressed during various stages of pancreas development and their role in β-cell specification. In addition, it also provides a perspective on the underlying molecular mechanisms.
ISSN:0065-2598
DOI:10.1007/5584_2023_778