PITUITARY GONADOTROPHIN INHIBITION BY SUBCUTANEOUSLY ADMINISTERED STEROIDS
ABSTRACT The anti-gonadotrophic activity of various new steroids was assessed by a parabiosis assay method using a normal female and a castrated male rat. 4-Chloro-17α-methyl-19-nortestosterone and 2α-methyl-17β-hydroxy-19-norandrostan-3-one showed a relatively high anti-pituitary activity and a hig...
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Published in | Acta endocrinologica (Copenhagen) Vol. 36; no. 1; pp. 83 - 86 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Denmark
01.01.1961
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Subjects | |
Online Access | Get full text |
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Summary: | ABSTRACT The anti-gonadotrophic activity of various new steroids was assessed by a parabiosis assay method using a normal female and a castrated male rat. 4-Chloro-17α-methyl-19-nortestosterone and 2α-methyl-17β-hydroxy-19-norandrostan-3-one showed a relatively high anti-pituitary activity and a high levator ani effect, while the stimulation of the seminal vesicles and prostate were minimum. 2α-Fluoro-17α-ethynyltestosterone and 2-benzoyloxymethylene-17α-methyl-17-β-hydroxyandrostan-3-one possess a disproportionately high anti-pituitary activity. |
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ISSN: | 0804-4643 0001-5598 1479-683X |
DOI: | 10.1530/acta.0.0360083 |