PITUITARY GONADOTROPHIN INHIBITION BY SUBCUTANEOUSLY ADMINISTERED STEROIDS

ABSTRACT The anti-gonadotrophic activity of various new steroids was assessed by a parabiosis assay method using a normal female and a castrated male rat. 4-Chloro-17α-methyl-19-nortestosterone and 2α-methyl-17β-hydroxy-19-norandrostan-3-one showed a relatively high anti-pituitary activity and a hig...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 36; no. 1; pp. 83 - 86
Main Authors KINCL, F A, RINGOLD, H J, DORFMAN, R I
Format Journal Article
LanguageEnglish
Published Denmark 01.01.1961
Subjects
Gonadal Steroid Hormones - pharmacology
Gonadotropins
Gonadotropins, Pituitary - antagonists & inhibitors
Humans
Pituitary Gland
GONADOTROPINS, PITUITARY/antagonists
SEX HORMONES/pharmacology
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Summary:ABSTRACT The anti-gonadotrophic activity of various new steroids was assessed by a parabiosis assay method using a normal female and a castrated male rat. 4-Chloro-17α-methyl-19-nortestosterone and 2α-methyl-17β-hydroxy-19-norandrostan-3-one showed a relatively high anti-pituitary activity and a high levator ani effect, while the stimulation of the seminal vesicles and prostate were minimum. 2α-Fluoro-17α-ethynyltestosterone and 2-benzoyloxymethylene-17α-methyl-17-β-hydroxyandrostan-3-one possess a disproportionately high anti-pituitary activity.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.0360083